1276121-40-4

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 186698-61-3 (S)-2-(tert-butoxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid 
• 1221593-77-6 1-[5(S)-(N'-Pbf-guanidino)-2-(2,4,6-triisopropyl-benzenesulfonylamino)-pentanoyl]-piperidine-4-carboxylic acid ethyl ester 
• 1221593-77-6 (S,E)-ethyl 1-(5-(2-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)-2-(2,4,6-triisopropylphenylsulfonamido)pentanoyl)piperidine-4-carboxylate 
• 1345596-37-3 1-[Arg(Pbf)]-piperidine-4-carboxylic acid ethyl ester hydrochloride 
• 200124-22-7 Boc-Arg-(Pbf)-OH 
• 1221593-74-3 (S,E)-ethyl 1-(2-(tert-butoxycarbonylamino)-5-(2-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoyl)piperidine-4-carboxylate 

Relevant academic research and scientific papers

Pharmaceutical compositions with attenuated release of phenolic opioids

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with th

COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.