127616-20-0

Upstream product

• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 123-72-8 butyraldehyde 
• 100-52-7 benzaldehyde 

Downstream Products

• 121830-00-0 2-Methyl-1-((1R,2S)-1-oxo-2-phenyl-1λ⁴-[1,3]dithian-2-yl)-butan-1-one 
• 121830-03-3 1-((1S,2R)-1-Oxo-2-phenyl-1λ⁴-[1,3]dithian-2-yl)-butan-1-one 
• 121830-03-3 1-((1R,2R)-1-Oxo-2-phenyl-1λ⁴-[1,3]dithian-2-yl)-butan-1-one 
• 20895-66-3 1-phenyl-1,2-pentanedione 
• 121830-02-2 1-(2-Phenyl-[1,3]dithian-2-yl)-butan-1-one 

Relevant academic research and scientific papers

A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: Application to fluorinated phenytoin synthesis

1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcoholis with NBS in aqueous acetone; phenytoin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

Diastereoselective Alkylation of Ketone Enolates using a 1,3-Dithiane 1-Oxide Auxiliary

Acyldithiane 1-oxides readily undergo deprotonation to give chelated metal enolates which react with iodomethane to give alkylated products with good selectivity.