127633-36-7

Usage

Chemical Properties

White product

InChI:InChI=1/C26H26NO8P/c1-32-36(31,33-2)35-18-13-11-17(12-14-18)15-24(25(28)29)27-26(30)34-16-23-21-9-5-3-7-19(21)20-8-4-6-10-22(20)23/h3-14,23-24H,15-16H2,1-2H3,(H,27,30)(H,28,29)/t24-/m0/s1

Upstream product

• 20621-25-4 dimethoxy(diethylamino)phosphine 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 118903-62-1 H-Tyr(PO₃Me₂)-OH*HCl 
• 127633-35-6 (S)-3-[4-(Dimethoxy-phosphoryloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 9,10-dioxo-9,10-dihydro-anthracen-2-ylmethyl ester 
• 127633-34-5 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-phenyl)-propionic acid 9,10-dioxo-9,10-dihydro-anthracen-2-ylmethyl ester 

Downstream Products

• 1030021-96-5 C₂₈H₄₂N₅O₁₄P 
• 1030021-84-1 Ac-Tyr(PO₃H₂)-Glu-Thr-Leu-Gly-OH 

Relevant academic research and scientific papers

Alternative Strategies for the Fmoc Solid-Phase Synthesis of O4-Phospho-L-tyrosine-Containing Peptides

A number of biologically relevant O4-phospho-L-tyrosine-containing peptides have been synthesized by either the global phosphorylation of the side-chain-unprotected L-tyrosine moiety in presynthesized resin-bound peptides or alternatively by the incorporation of suitable protected O4-phospho-L-tyrosine building blocks in the continuous-flow method of Fmoc solid-phase peptide synthesis.Different phosphate-protecting groups have been applied.

Fmoc-polyamide solid phase synthesis of an O-phosphotyrosine-containing tridecapeptide

The incorporation of O-phosphotyrosine into synthetic peptides using Fmoc-Tyr(PO3Me2)-OH in the Fmoc-polyamide procedure is described with the preparation of the model PTyr-tridecapeptide sequence H-Arg-Leu-Ile-Glu-Asp-Asn-Glu-PTyr-T