127648-93-5

Basic information

• Product Name: 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine
• Synonyms: 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine
• CAS NO: 127648-93-5
• Molecular Weight: 438.482
• Mol File: 127648-93-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine(127648-93-5)
• EPA Substance Registry System: 1-methyl-5-(2'-fluoro-4'-nitrophenyl)-2-(3'-thienylcarboxamido)-methyl-2H-1,4-benzodiazepine(127648-93-5)

Safety Data

• Hazardous Substances Data: 127648-93-5(Hazardous Substances Data)

Upstream product

• 41507-35-1 3-thiophene carboxylic acid chloride 
• 127648-92-4 C-[5-(2-Fluoro-4-nitro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl]-methylamine 
• 127648-91-3 1-methyl-2-(N-phthalimidomethyl)-5-(2'-fluoro-4'-nitrophenyl)-2H-1,4-benzodiazepine 
• 127648-90-2 2-Chloromethyl-5-(2-fluoro-4-nitro-phenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepine 
• 88-13-1 3-Thiophene carboxylic acid 

Relevant articles and documents

Opioid ligands related to tifluadom

In an effort to prepare ligands with kappa selective affintity suitable for use in affinity chromatography, we synthesized the haloacetamido derivatives 17 and 18 of tifluadom.These compounds showed modest opioid binding affinity but were more active at the mu than at the kappa site.The nitro compounds 7 and 16 were prepared as potential intermediates.The former, a weak mu agonist, was devoid of kappa affinity (IC50 > 1E-6 M), whereas the latter was a mu selective agonist.Keywords: tifluadom/ benzodiazepines/ affinity chromathography/ opioid binding activity