127653-08-1

Upstream product

• 127653-00-3 C₂₂H₂₂O₄ 
• 127653-30-9 (4-methoxymethoxymethylphenyl)-methanal 
• 10602-04-7 (4-ethynylphenyl)methanol 
• 275386-60-2 4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene 
• 873-75-6 4-bromobenzenemethanol 
• 127653-33-2 1-(2,2-Dibromo-vinyl)-4-methoxymethoxymethyl-benzene 
• 127653-36-5 1-Ethynyl-4-methoxymethoxymethyl-benzene 

Downstream Products

• 127653-16-1 4,4'-(buta-1,3-diyne-1,4-diyl)dibenzaldehyde 

Relevant academic research and scientific papers

Copper-catalyzed oxidative alkyne homocoupling without palladium, ligands and bases

Copper-catalyzed green oxidative homocoupling of terminal alkynes can be run to produce symmetrical 1,4-disubstituted 1,3-diynes in good to excellent yields, using air as environmentally friendly oxidant and the occurrence of water as exclusive byproduct in the whole process. This eliminates the need for ligands, bases, oxidants and expensive palladium catalysts.

Twisting of Alkynes towards a Carbon Double Helix

The carbon allotrope exhibiting only one-dimensional sp-hybridized carbon atoms is called carbyne. However, its existence is very controversial. Studies on model compounds for carbyne revealed that many oligoalkynes show not a straight, but a bent structu

Real-time monitoring of pharmacokinetics of mitochondria-targeting molecules in live cells with bioorthogonal hyperspectral stimulated raman scattering microscopy

The dynamics of mitochondria in live cells play a pivotal role in biological events such as cell metabolism, early stage apoptosis, and cell differentiation. Triphenylphosphonium (TPP) is a commonly used mitochondria-targeting agent for mitochondrial stud

Development of solid-supported Glaser-Hay couplings

While the Glaser-Hay coupling of terminal alkynes is a useful reaction, several issues associated with chemoselectivity preclude its widespread application in synthetic chemistry. To address these issues, a solid-supported Glaser-Hay methodology was developed to afford only asymmetric diyne products. This methodology was then applied to a series of immobilized alkynes with a diverse set of soluble alkynes to generate an array of heterocoupled products in high yields and purities.