127658-17-7Relevant academic research and scientific papers
ASYMMETRIC DIELS-ALDER REACTIONS: EPC-SYNTHESIS OF A STABLE SARKOMYCIN PRECURSOR (CYCLOSARKOMYCIN)
Linz, Guenter,Weetman, John,Hady, A. F. Abdel,Helmchen, Guenter
, p. 5599 - 5602 (2007/10/02)
The first synthesis of enantiomerically pure cyclosarkomycin, a stable, crystaline precursor of the antitumor agent sarkomycin is reported.Key steps are an asymmetric Diels-Alder reaction of the (E)-3-bromoacrylate of (R)-pantolactone and introduction of oxygen funtionality via elimination/β-addition.The synthesis of cyclosarkomycin was accomplished in 9 steps in 17 percent overall yield.
