127680-28-8

Basic information

• Product Name: 2-Azetidinone, 3-chloro-4-phenyl-1-(phenylmethyl)-, (3R,4S)-rel-
• CAS NO: 127680-28-8
• Molecular Formula: C16H14ClNO
• Molecular Weight: 271.746
• Mol File: 127680-28-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Azetidinone, 3-chloro-4-phenyl-1-(phenylmethyl)-, (3R,4S)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinone, 3-chloro-4-phenyl-1-(phenylmethyl)-, (3R,4S)-rel-(127680-28-8)
• EPA Substance Registry System: 2-Azetidinone, 3-chloro-4-phenyl-1-(phenylmethyl)-, (3R,4S)-rel-(127680-28-8)

Safety Data

• Hazardous Substances Data: 127680-28-8(Hazardous Substances Data)

Upstream product

• 780-25-6 N-benzylidene benzylamine 
• 79-04-9 chloroacetyl chloride 
• 100-46-9 benzylamine 
• 5464-70-0 2,3-dibromo-3-phenyl-propionic acid ethyl ester 
• 57880-75-8 1-benzyl-3,3-dichloro-4-phenyl-2-azetidinone 
• 108-24-7 acetic anhydride 

Relevant articles and documents

The halogen-lithium exchange reaction of 3,3-dichloro-2-azetidinones: Application to the synthesis of cis-4-aryl-3-chloro-2-azetidinones

A straightforward synthesis of new cis-4-aryl-3-chloro-2-azetidinones was developed, using a halogen-lithium exchange reaction on 4-aryl-3,3-dichloro-2- azetidinones. This methodology was further extended to the use of alkyl halides as electrophiles, while more complex electrophiles could not be introduced.

Aziridines as templates: A general strategy for the stereospecific synthesis of 2-azetidinones

Various routes to a variety of azridine-2-carboxylates have been described and the stereochemistry of these compounds has been determined by spectroscopic methods. Further, greater diversity of β-lactams via ring expansion of these azridines-2-carboxylates were obtained by a general, efficient and direct stereospecific approach.