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Usage

Uses

Used in Pharmaceutical Synthesis:
2-(propylamino)isonicotinonitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the creation of biologically active molecules. Its chemical properties allow it to be a key component in the development of new drugs.
Used in Agrochemical Production:
In the agrochemical industry, 2-(propylamino)isonicotinonitrile serves as an intermediate, playing a crucial role in the synthesis of compounds that have applications in agriculture, such as pesticides and herbicides, due to its potential to form active ingredients with desired properties.
Used in Medicinal Chemistry Research:
2-(propylamino)isonicotinonitrile is utilized as a research tool in medicinal chemistry, where its reactivity and structural features are explored to understand and develop new chemical entities with therapeutic potential. Its role in this field is significant for advancing the discovery and design of novel pharmaceuticals.

Upstream product

• 107-10-8 propylamine 
• 29181-50-8 2,4-Dicyanopyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 

Relevant academic research and scientific papers

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.

A Study of the Photochemically Induced Reaction of Pyridine-2,4-dicarbonitrile with Primary and Secondary Amines. A Direct Synthesis of Aminocyanopyridines

A novel synthesis of alkylaminopyridinecarbonitriles by a photoinitiated substitution reaction between pyridine-2,4-dicarbonitrile and certain amines is described.The mechanism is discussed.