127680-86-8

Basic information

• Product Name: 2-Cyano-4-(pyrrolidin-1-yl)pyridine
• Synonyms: 2-Cyano-4-(pyrrolidin-1-yl)pyridine;4-(Pyrrolidin-1-yl)picolinonitrile;4-(1-pyrrolidinyl)-2-Pyridinecarbonitrile
• CAS NO: 127680-86-8
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173
• Mol File: 127680-86-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Cyano-4-(pyrrolidin-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-4-(pyrrolidin-1-yl)pyridine(127680-86-8)
• EPA Substance Registry System: 2-Cyano-4-(pyrrolidin-1-yl)pyridine(127680-86-8)

Safety Data

• Hazardous Substances Data: 127680-86-8(Hazardous Substances Data)

Usage

General Description

2-Cyano-4-(pyrrolidin-1-yl)pyridine is a chemical compound with the molecular formula C9H10N3. It falls under the category of organoheterocyclic compounds, specifically those containing a pyridine ring. Pyridines are compounds containing a pyridine ring, which is a six-membered aromatic heterocycle, with nitrogen atoms replacing two carbons of the ring. In 2-Cyano-4-(pyrrolidin-1-yl)pyridine, a pyrrolidine ring is attached to the pyridine ring. Pyrrolidines are compounds that contain a pyrrolidine ring, which is a saturated five-membered ring with one nitrogen atom and four carbon atoms. This chemical is not very common and its properties are still being explored for possible applications.

Upstream product

• 123-75-1 pyrrolidine 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 
• 29181-50-8 2,4-Dicyanopyridine 

Relevant articles and documents

4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents

The series of new 4-substituted picolinohydrazonamides were synthesized (6-25) and evaluated for tuberculostatic activity. Compounds having a hydrophilic cyclic amine such as morpholine and pyrrolidine at the end of the thiosemicarbazide chain, exhibited the highest antimycobacterial activity. The antimycobacterial activity of compounds 6, 11, and 15 (MIC 0.4–0.8 μg/mL) was higher than that of reference drugs. Moreover, derivative 15 exhibited lower activity against other tested microorganism such as bacteria gram-positive, gram-negative or fungi. Thus, this compound is characterized by the selectivity of antimicrobial activity. Antiproliferative study conducted against human dermal fibroblasts (HDF) and mouse melanoma cell line (B16-F10) revealed low cytotoxicity of compound 15. Conducted research allowed to identify compound 15 as leading for further research.

A Study of the Photochemically Induced Reaction of Pyridine-2,4-dicarbonitrile with Primary and Secondary Amines. A Direct Synthesis of Aminocyanopyridines

A novel synthesis of alkylaminopyridinecarbonitriles by a photoinitiated substitution reaction between pyridine-2,4-dicarbonitrile and certain amines is described.The mechanism is discussed.