127682-43-3

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 1239023-75-6 C₂₅H₁₂F₁₈N₂O₄ 
• 372-20-3 3-fluorophenol 
• 768-35-4 3-fluorophenylboronic acid 

Downstream Products

• 372-20-3 3-fluorophenol 
• 399-95-1 4-amino-3-fluorophenol 
• 53981-24-1 2-amino-5-fluorophenol 
• 53981-23-0 2-amino-3-fluorophenol 
• 1603901-11-6 (Z)-2-(2,6-difluorophenyl)-1-(4-(2-methyl-5-(2,2,2-trifluoro-1-(3-fluorophenoxyimino)ethyl)pyrimidin-4-yl)piperidin-1-yl)ethanone 
• 1603901-13-8 (E)-2-(2,6-difluorophenyl)-1-(4-(2-methyl-5-(2,2,2-trifluoro-1-(3-fluorophenoxyimino)ethyl)pyrimidin-4-yl)piperidin-1-yl)ethanone 

Relevant academic research and scientific papers

Unnatural Amino Acid Synthesis Enabled by the Regioselective Cobalt(III)-Catalyzed Intermolecular Carboamination of Alkenes

Herein, we report an unprecedented regioselective and entirely atom-economic cobalt(III)-catalyzed method for the non-annulative, intermolecular carboamination of alkenes. The methodology enables the direct synthesis of unnatural amino acid derivatives an

An Activity-Based Sensing Fluorogenic Probe for Monitoring Ethylene in Living Cells and Plants

Ethylene (ET) is an important gaseous plant hormone. It is highly desirable to develop fluorescent probes for monitoring ethylene in living cells. We report an efficient RhIII-catalysed coupling of N-phenoxyacetamides to ethylene in the presenc

Rh(iii)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates

Here we report a new and mild Rh(iii)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates. This reaction provided a straightforward way for installing both an α-quaternary carbon center and a free-OH moiety into the phenyl ring, thus giving access to useful 2-(2-hydroxyphenyl)-2-alkoxymalonates with good substrate/functional group tolerance. This journal is

Rhodium(iii)-catalyzed C-H activation/[4+3] annulation of N-phenoxyacetamides and α,β-unsaturated aldehydes: An efficient route to 1,2-oxazepines at room temperature

An efficient Rh(iii)-catalyzed coupling reaction of N-phenoxyacetamides with α,β-unsaturated aldehydes to give 1,2-oxazepines via C-H activation/[4+3] annulation has been developed. This transformation does not require oxidants and features C-C/C-N bond formation to yield seven-membered oxazepine rings at room temperature. Further derivation of 1,2-oxazepines leads to important chroman derivatives. This journal is

Fluorous tagged N-hydroxy phthalimide for the parallel synthesis of O-aryloxyamines

The parallel synthesis of O-aryloxyamines remains an unfulfilled need in the field of medicinal chemistry and fragment-based approaches. To fill this gap a solution-phase two-step process based on (1) a copper-catalyzed cross-coupling of aryl boronic acid