127682-56-8

Upstream product

• 50-89-5 thymidine 
• 127682-54-6 3'-deoxy-3'-methylthio-5'-O-tritylthymidine 
• 909256-85-5 O²,3'-anhydro-1-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)thymine 
• 42214-24-4 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine 
• 76-83-5 trityl chloride 

Downstream Products

• 131607-35-7 3'-deoxy-3'-C-methylidene-5'-O-(triphenylmethyl)thymidine 

Relevant academic research and scientific papers

SO2-extrusion reactions of sulfonylated nucleosides: A novel strategy for the synthesis of exocyclic olefinic thymidines

Analogues of 3′-C-methylidene-2′,3′-dideoxy-5- methyluridine have been synthesized from the 3′-deoxy-3′- sulfonylated derivatives of thymidine using sulfur dioxide extrusion reaction. Georg Thieme Verlag Stuttgart.

Synthesis of 3'-Fluoromethylthio-, 3'-Fluoromethylsulfinyl- and 3'-Fluoromethylsulfonyl-substituted 3'-Deoxythymidine

3'-Deoxy-3'-(fluoromethylthio)thymidine 2 is synthesized from 5'-O-benzoyl-3'-deoxy-3'-(methylsulfinyl)thymidine 9 by using DAST. 5'-O-Benzoyl-3'-deoxy-3'-(fluoromethylthio)thymidine is used as starting material for the synthesis of the sulfoxide 3 and the sulfone 4.Both sulfoxides 3A and 3B show a C3'-endo sugar conformation.