127684-25-7Relevant academic research and scientific papers
CoA-IT and PAF inhibitors
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, (2008/06/13)
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.
Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles
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, (2008/06/13)
Antihypercholesterolemic thioimidazoles of the formula STR1 or a pharmaceutical acceptable salt thereof, wherein R1 and R2 independently are H, F, Cl, CF3, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms; A
