12769-48-1

Basic information

• Product Name: SUBSTANCE P
• Synonyms: RPKPQQFFGLM-NH2;RPKPQFFGLM;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P BOVINE;SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];SUBSTANCE P AMIDE;SUBSTANCE P;SUBSTANCE P (TYR8)
• CAS NO: 12769-48-1
• Molecular Formula: C63H98N18O13S
• Molecular Weight: 1347.63
• EINECS: 251-545-8
• Mol File: 12769-48-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.42g/cm³
• Refractive Index: 1.662
• Storage Temp.: -20°C
• CAS DataBase Reference: SUBSTANCE P(CAS DataBase Reference)
• NIST Chemistry Reference: SUBSTANCE P(12769-48-1)
• EPA Substance Registry System: SUBSTANCE P(12769-48-1)

Safety Data

• Hazardous Substances Data: 12769-48-1(Hazardous Substances Data)

Usage

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Mechanism of action

Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.

Clinical Use

The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.

InChI:InChI=1/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1

Related news

PEGylated SUBSTANCE P (cas 12769-48-1) augments therapeutic angiogenesis in diabetic critical limb ischemia09/03/2019

Substance P (SP) is a therapeutic peptide that has been widely used to induce angiogenesis and tissue regeneration. However, its therapeutic efficacy is often limited due to rapid degradation in vivo and a short half-life (˜1 min) after systemic administration. In the present study, we chemicall...detailed

News and reviewsRole of SUBSTANCE P (cas 12769-48-1) in the cardiovascular system09/02/2019

This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions of substance P are mainl...detailed

SUBSTANCE P (cas 12769-48-1) improves MSC-mediated RPE regeneration by modulating PDGF-BB08/30/2019

Stem cells have regenerative potentials that can be used for the treatment of critical and incurable diseases. Age-related macular degeneration (ARMD) and diabetic retinopathy are one of the most severe retinal disorders, which are mostly attributed to impairment of retinal pigmented epithelium ...detailed

SUBSTANCE P (cas 12769-48-1) plays a critical role in synaptic transmission in striatal neurons08/28/2019

Substance P is one of the major neuropeptides released by striatal neurons; however, its function in the striatum remains unclear. In this study, we found substance P triggers spontaneous neurotransmitter release and rapid synaptic vesicle exocytosis in cultured striatal neurons, as substance P ...detailed