1277102-72-3Relevant academic research and scientific papers
Iron(iii)-salan complexes catalysed highly enantioselective fluorination and hydroxylation of β-keto esters and N-Boc oxindoles
Gu, Xin,Zhang, Yan,Xu, Zhen-Jiang,Che, Chi-Ming
, p. 7870 - 7873 (2014/07/08)
Chiral iron(iii)-salan complexes catalysed highly enantioselective α-fluorination and α-hydroxylation of β-keto esters and N-Boc oxindoles to give the corresponding products in high yields and good-to-excellent ee values under mild reaction conditions. This journal is the Partner Organisations 2014.
Enantioselective synthesis of α-halo-α-alkylmalonates via phase-transfer catalytic α-alkylation
Hong, Suckchang,Kim, Minsik,Jung, Myunggi,Ha, Min Woo,Lee, Myungmo,Park, Yohan,Kim, Mi-Hyun,Kim, Taek-Soo,Lee, Jihoon,Park, Hyeung-Geun
, p. 1510 - 1517 (2014/03/21)
A new enantioselective synthetic method for α-halo-α- alkylmalonates is reported. α-Alkylation of diphenylmethyl tert-butyl α-halomalonates under phase-transfer catalytic conditions (solid KOH, toluene, -40 °C) in the presence of (S,S)-3,4,5-trifluorophen
Highly enantioselective synthesis of α,α-dialkylmalonates by phase-transfer catalytic desymmetrization
Hong, Suckchang,Lee, Jihye,Kim, Minsik,Park, Yohan,Park, Cheonhyoung,Kim, Mi-Hyun,Jew, Sang-Sup,Park, Hyeung-Geun
, p. 4924 - 4929 (2011/06/10)
A novel enantioselective synthetic method for the construction of a quaternary carbon center from malonates via phase-transfer catalytic (PTC) alkylation has been developed. The asymmetric α-alkylation of diphenylmethyl tert-butyl α-alkylmalonates with alkylating agents under phase-transfer catalysis conditions (aq 50% KOH, toluene, 0°C) in the presence of (S,S)-3,4,5-trifluorophenyl-NAS bromide (8) as PTC catalyst afforded the corresponding α,α-dialkylmalonates in high chemical (up to 99%) and optical yields (up to 97% ee) which could be readily converted to versatile chiral intermediates. Notably, the direct double α-alkylations of diphenylmethyl tert-butyl malonate also provided the corresponding α,α-dialkylmalonates without loss of enantioselectivity. The synthetic potential of this method has been demonstrated by the preparation of α,α-dialkylamino acid and oxindole systems.
