4491-46-7

Basic information

• Product Name: 2-benzyl-malonic acid tert-butyl ester methyl ester
• Synonyms: 2-benzyl-malonic acid tert-butyl ester methyl ester
• CAS NO: 4491-46-7
• Molecular Weight: 264.321
• Mol File: 4491-46-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-benzyl-malonic acid tert-butyl ester methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-malonic acid tert-butyl ester methyl ester(4491-46-7)
• EPA Substance Registry System: 2-benzyl-malonic acid tert-butyl ester methyl ester(4491-46-7)

Safety Data

• Hazardous Substances Data: 4491-46-7(Hazardous Substances Data)

Upstream product

• 60084-69-7 2-benzyl-3-(tert-butoxy)-3-oxopropanoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 1663-39-4 tert-Butyl acrylate 
• 42726-73-8 methyl t-butyl malonate 
• 100-39-0 benzyl bromide 
• 132180-14-4 O₁-tert-butyl O₃-methyl 2-methylpropanedioate 
• 40052-13-9 mono-tert-butyl malonate 
• 186581-53-3 diazomethane 
• 3709-27-1 5-benzyl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1007121-07-4 (S)-1-tert-butyl 3-methyl 2-benzyl-2-fluoromalonate 
• 1277102-72-3 (R)-1-tert-butyl 3-methyl 2-fluoro-2-benzylmalonate 
• 1430104-31-6 (5R)-benzyl-N-(3,5-dimethoxybenzyl)-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carboxamide 
• 1241794-93-3 tert-butyl methyl (R)-2-(benzoyloxy)-2-benzylmalonate 

Relevant articles and documents

Cobalt-Catalyzed Highly Regioselective Three-Component Arylcarboxylation of Acrylate with Aryl Bromides and Carbon Dioxide

Cobalt-catalyzed regioselective three-component arylcarboxylation of acrylate with aryl bromides and carbon dioxide has been developed. The reaction is carried out by using cobalt chloride as a precatalyst and zinc powder as a reducing reagent under CO2 (1 atm) at 40 °C. A range of aryl bromides are used for this reaction, leading to a series of valuable carboxylic acids with high regioselectivity and functional-group compatibility. Mechanistic experiments and DFT calculations indicate that this arylcarboxylation reaction involves the reaction of CO2 with a cobalt enolate intermediate to form the C?C bond.

Enantioselective α-Benzoyloxylation of Malonic Diesters by Phase-Transfer Catalysis

A highly enantioselective α-benzoyloxylation of malonic diester has been achieved by phase-transfer catalysis. The reaction of α-monosubstituted tert-butyl methyl malonate with benzoyl peroxide in the presence of aqueous KOH and N-(9-anthracenylmethyl)cinchoninium chloride afforded the corresponding α,α-disubstituted products in generally excellent chemical yields (up to 99% yield) with high enantioselectivities (up to 96% ee). In addition, the utility of this methodology was exhibited by the synthesis of a mineralocorticoid receptor antagonist.

Iron(iii)-salan complexes catalysed highly enantioselective fluorination and hydroxylation of β-keto esters and N-Boc oxindoles

Chiral iron(iii)-salan complexes catalysed highly enantioselective α-fluorination and α-hydroxylation of β-keto esters and N-Boc oxindoles to give the corresponding products in high yields and good-to-excellent ee values under mild reaction conditions. This journal is the Partner Organisations 2014.