1277149-85-5Relevant academic research and scientific papers
Synthesis of iminonitriles by oxone/tbab-mediated one-pot oxidative three-component strecker reaction
Gualtierotti, Jean-Baptiste,Schumacher, Xavier,Wang, Qian,Zhu, Jieping
, p. 1380 - 1386 (2013/07/05)
Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.
Enantioselective rhodium-catalyzed [4 + 2] cycloaddition of α,β-unsaturated imines and isocyanates
Oberg, Kevin M.,Rovis, Tomislav
supporting information; experimental part, p. 4785 - 4787 (2011/05/16)
A [4 + 2] cycloaddition of α,β-unsaturated imines and isocyanates catalyzed by a phosphoramidite-rhodium complex provides pyrimidinones in good yields and high enantioselectivities.
