158657-48-8

Upstream product

• 1277149-85-5 1-benzyl-4-(4-methoxyphenyl)-1-azabuta-1,3-diene 
• 75-07-0 acetaldehyde 
• 14371-10-9 (E)-3-phenylpropenal 
• 50-00-0 formaldehyd 
• 2393-23-9 4-methoxy-benzylamine 
• 60960-88-5 (E)-N-methylcinnamylamine 
• 824-94-2 p-methoxybenzyl chloride 
• 1586-98-7 (2,3-dibromopropyl)benzene 
• 702-24-9 4-methoxy-N-methylbenzylamine 
• 300-57-2 allylbenzene 

Downstream Products

• 474519-47-6 4-hydroxy-N-methyl-N-(3-phenyl-2(E)-propenyl)-benzene-methanamine 

Relevant academic research and scientific papers

Application of naftifine analogue in control of agricultural plant diseases

The invention discloses application of any compound of naftifine analogues H-01 to H-22 in control of agricultural plant fungal diseases. Biological activity tests indicate that the derivatives show certain inhibitory activity on the six plant diseases, i

CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence

Enantioenriched molecules bearing indole-substituted stereocenters form a class of privileged compounds in biological, medicinal, and organic chemistry. Thus, the development of methods for asymmetric indole alkylation is highly valuable in organic synthesis. Traditionally, achieving N-selectivity in indole alkylation reactions is a significant challenge, since there is an intrinsic preference for alkylation at C3, the most nucleophilic position. Furthermore, selective and predictable access to either N- or C3-alkylated chiral indoles using catalyst control has been a long-standing goal in indole functionalization. Herein, we report a ligand-controlled regiodivergent synthesis of N- and C3-alkylated chiral indoles that relies on a polarity reversal strategy. In contrast to conventional alkylation reactions in which indoles are employed as nucleophiles, this transformation employs electrophilic indole derivatives, N-(benzoyloxy)indoles, as coupling partners. N- or C3-alkylated indoles are prepared with high levels of regio- and enantioselectivity using a copper hydride catalyst. The regioselectivity is governed by the use of either DTBM-SEGPHOS or Ph-BPE as the supporting ligand. Density functional theory (DFT) calculations are conducted to elucidate the origin of the ligand-controlled regiodivergence.

Practical regio- and stereoselective azidation and amination of terminal alkenes

There is significant interest in developing more rapid and efficient production of nitrogen-containing allylic compounds, as widely used in various syntheses. This work reports a variety of allylic azides and allylic amines synthesized by an efficient, new one-pot protocol that employs readily available terminal alkenes as starting materials. This method is highly regio- and stereoselective, affording the linear (E)-isomer, under metal-free conditions. This process tolerates several functional groups including halogen-containing molecules; it is general for azides and amine nucleophiles; and, adducts were obtained in good yields.

Novel azole or triazole derivatives, method for preparing same and use thereof as fungicides

The invention concerns novel azole or triazole derivatives of formula (I), wherein X, Ar1, Ar2, Ar3, A, B, and R1 are as defined herein, their preparation method and their use as fungicides.

Novel azole or triazole derivatives, method for preparing the same and use thereof as antifungal medicaments

The invention concerns novel azole or triazole derivatives of formula (I), wherein: X, Ar1, Ar3, A, R1, R5, R6, R7 and B are such as defined in the description, their preparation method and their use as antifungal medicines.