1277150-38-5

Basic information

• Product Name: (R)-(+)-4-phenyltetrahydropyrimidin-2(1H)-one
• Synonyms: (R)-(+)-4-phenyltetrahydropyrimidin-2(1H)-one
• CAS NO: 1277150-38-5
• Molecular Weight: 176.218
• Mol File: 1277150-38-5.mol

Chemical Properties

• CAS DataBase Reference: (R)-(+)-4-phenyltetrahydropyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-4-phenyltetrahydropyrimidin-2(1H)-one(1277150-38-5)
• EPA Substance Registry System: (R)-(+)-4-phenyltetrahydropyrimidin-2(1H)-one(1277150-38-5)

Safety Data

• Hazardous Substances Data: 1277150-38-5(Hazardous Substances Data)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 1277150-33-0 (R)-1,3-bis(4-methoxybenzyl)-4-phenyl-3,4-dihydropyrimidin-2-one 
• 1277150-36-3 (R)-1,3-bis(4-methoxybenzyl)-4-phenyltetrahydropyrimidin-2-one 
• 1064162-31-7 1-(4-methoxybenzyl)-4-phenyl-1-azabuta-1,3-diene 
• 38675-31-9 2-hydroxy-4-phenylpyrimidine 

Relevant articles and documents

Method for synthesizing chiral cyclic urea by asymmetric hydrogenation of 2-hydroxy pyrimidine compounds catalyzed by iridium

The invention provides a method for synthesizing chiral cyclic urea by asymmetric hydrogenation of 2-hydroxy pyrimidine compounds catalyzed by iridium. In the formula described below, R refers to alkyl or aryl of C1-C6; R' refers to aryl, heteroaryl or alkyl containing substituents, and the substituent contains at least one of F, Cl, CF3, Me and MeO, and the enantiomeric excess of the synthesizedchiral cyclic urea can reach 96%. The method is simple to operate and practical and easy to implement, high in the yield, environmental friendly, commercially available for catalysts and moderate in reaction condition and has potential practical application value.

Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of 2-Hydroxypyrimidine/Pyrimidin-2(1H)-one Tautomers

A facile access to optically active cyclic ureas was developed through palladium-catalyzed asymmetric hydrogenation of pyrimidines containing tautomeric hydroxy group with up to 99 % ee. Mechanistic studies indicated that reaction pathway proceed through

Enantioselective rhodium-catalyzed [4 + 2] cycloaddition of α,β-unsaturated imines and isocyanates

A [4 + 2] cycloaddition of α,β-unsaturated imines and isocyanates catalyzed by a phosphoramidite-rhodium complex provides pyrimidinones in good yields and high enantioselectivities.