38675-31-9

Basic information

• Product Name: 4-PHENYLPYRIMIDIN-2-OL
• Synonyms: 4-PHENYLPYRIMIDIN-2-OL
• CAS NO: 38675-31-9
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Mol File: 38675-31-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-PHENYLPYRIMIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLPYRIMIDIN-2-OL(38675-31-9)
• EPA Substance Registry System: 4-PHENYLPYRIMIDIN-2-OL(38675-31-9)

Safety Data

• Hazardous Substances Data: 38675-31-9(Hazardous Substances Data)

Usage

General Description

4-Phenylpyrimidin-2-ol is a chemical compound with the molecular formula C11H9N3O. It is a pyrimidine derivative containing a phenyl group and a hydroxyl group attached to the pyrimidine ring. 4-PHENYLPYRIMIDIN-2-OL has applications in organic chemistry and pharmaceutical research, where it is used as a building block in the synthesis of various organic compounds and drug molecules. It may also have potential biological activities and pharmacological properties that make it a subject of interest in drug discovery and development. Overall, 4-phenylpyrimidin-2-ol is a versatile chemical with diverse potential applications in various fields of science and technology.

Upstream product

• 13036-50-5 2-chloro-4-phenylpyrimidine 
• 2305-87-5 4-phenylpyrimidin-2-amine 
• 768-03-6 Phenyl vinyl ketone 
• 98-80-6 phenylboronic acid 
• 58006-76-1 4,7-dihydro-5-phenyl-1,2,4-oxadiazepin-3(2H)-one 
• 15397-33-8 3-Oxo-3-phenylpropanal 

Downstream Products

• 13036-50-5 2-chloro-4-phenylpyrimidine 
• 762302-95-4 1-(4-chlorobutyl)-4-phenylpyrimidin-2(1H)-one 

Relevant articles and documents

Identification of N-arylsulfonylpyrimidones as anticancer agents

For confirming the role of five membered ring of imidazolidinone moiety of N-arylsulfonylimidazolidinones (7) previously reported with highly potent anticancer agent, a series of N-arylsulfonylpyrimidones (10a–g) and N-arylsulfonyltetrahydropyrimidones (11a–e) were prepared and their anti-proliferating activity was measured against human cancer cell lines (renal ACHN, colon HCT-15, breast MDA-MB-231, lung NCI-H23, stomach NUGC-3, and prostate PC-3) using XTT assay. Among them, 1-(1-acetylindolin-5-ylsulfonyl)-4-phenyltetrahydropyrimidin-2(1H)-one (11d, mean GI50?=?3.50?μM) and ethyl 5-(2-oxo-4-phenyltetrahydropyrimidin-1(2H)-ylsulfonyl)-indoline-1-carboxylate (11e, mean GI50?=?0.26?μM) showed best growth inhibitory activity against human cancer cell lines. Considering the activity results, N-arylsulfonyltetrahydropyrimidones (11) exhibited more potent activity compared to N-arylsulfonylpyrimidones (10) and comparable activity to N-arylsulfonylimidazolidinones (7). Especially, tetrahydropyrimidin-2(1H)-one analogs containing acylindolin-5-ylsulfonyl moiety at position 1 demonstrated their strong growth inhibitory activity against human cancer cell lines.

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.COPYRIGHT KIPO 2016

SYNTHESIS OF SUBSTITUTED 2- AND 4-HYDROXYAMINOPYRIMIDINES

The reaction of 2- and 4-chlorine-containing alkyl(aryl)pyrimidines with hydroxylamine was studied.It was shown that, depending on the amount of hydroxylamine , N,O-dipyrimidinylhydroxyamides or the corresponding 2- and 4-hydroxyaminopyrimidines are formed together with 2- and 4-oxodihydropyrimidines.