727726-52-5

Upstream product

• 727726-43-4 2-[[1-[(2S)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione 
• 139017-02-0 (+)-4(S)-methyl-2,2-diphenyl-1-oxa-2-silacyclopentane 
• 1277183-00-2 fluoro(3-hydroxy-2-methylpropan-1-yl)diphenylsilane 
• 775-12-2 diphenylsilane 
• 139016-78-7 1-(2-methyl-2-propenyl) diphenylsilyl ether 
• 1277183-02-4 (R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide 
• 1277183-01-3 (+)-(S)-1-(3-methoxymethoxy-2-methylpropyl)diphenylsilane 
• 727726-45-6 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][1-(benzoylamino)-2-phenylethyl]diphenylsilane 
• 727726-29-6 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][2-(phenylmethyl)-1,3-dithian-2-yl]diphenylsilane 
• 727726-32-1 [(2S)-2-methyl-3-hydroxy-1-propyl][(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilane 
• 727726-39-8 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-oxoethyl]diphenylsilane 
• 727726-41-2 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-hydroxyethyl]diphenylsilane 
• 727726-30-9 [2-(phenylmethyl)-1,3-dithian-2-yl]fluorodiphenylsilane 
• 31593-52-9 2-benzyl-1,3-dithiane 

Downstream Products

• 727726-34-3 (2S)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester 
• 727726-28-5 (S)-1-{(S)-3-[((R)-1-benzamido-2-phenylethyl)difluoro sily-l]-2-methylpropanoyl}pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

An effective total synthesis of four angiotensin-converting enzymes containing silanediols

Four angiotensin-converting enzymes (ACE) containing silanediols 1 have been synthesized successfully in 8% overall yield in 8 steps from inexpensive starting materials such as diphenyldichlorosilane 5, β-methylallylic alcohol 7 and Ellman sulfinimine 9.

Efficient, enantioselective assembly of silanediol protease inhibitors

A five-step assembly of silicon-protected dipeptide mimics from commercially available reagents is described. This methodology makes silanediol protease inhibitors readily available for the first time. The sequence features asymmetric hydrosilylation, a novel reduction of a silyl ether to a silyllithium reagent, and addition of this dianion to a sulfinimine, to produce the complete inhibitor skeleton with full control of stereochemistry. Oxidation of the primary alcohol to an acid completes the synthesis.

Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues

Four stereoisomers of a Phe-Ala silanediol dipeptide mimic have been evaluated as inhibitors of angiotensin-converting enzyme (ACE) and compared to ketone-based inhibitors reported by Almquist et al. One stereogenic center of the isomers was derived from

Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors

Four diastereomers of a Phe-Ala peptide mimic incorporating a central silanediol group have been individually prepared and tested as inhibitors of angiotensin-converting enzyme (ACE). Three of the silanediols exhibit levels of inhibition that are similar