127720-99-4

Usage

InChI:InChI=1/C12H12N4O3/c1-2-19-12(18)10-14-9(13)11(17)16(15-10)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,13,14,15)

Upstream product

• 898-22-6 triethyl 1,3,5-triazine-2,4,6-tricarboxylate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 127721-00-0 (5-amino-6-oxo-1-phenyl-1,6-dihydro-1,2,4-triazinyl-3)carboxylic acid 
• 127721-03-3 5,6-dioxo-1-phenyl-3-ethoxycarbonyl-1,4,5,6-tetrahydro-1,2,4-triazine 
• 127721-04-4 5-Amino-6-oxo-1-phenyl-1,6-dihydro-[1,2,4]triazine-3-carboxylic acid methyl ester 
• 127721-05-5 5-N-methylamino-3-methoxycarbonyl-6-oxo-1-phenyl-1,6-dihydro-1,2,4-triazine 
• 127721-06-6 4-N-methyl-5,6-dioxo-1-phenyl-3-ethoxycarbonyl-1,4,5,6-tetrahydro-1,2,4-triazine 
• 127721-07-7 5-Methylamino-6-oxo-1-phenyl-1,6-dihydro-[1,2,4]triazine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Preparation of 5-amino-6-oxo-1,6-dihydro[1,2,4]triazine-3-carboxylic acid derivatives and synthesis of compound libraries thereof

Treatment of [1,3,5]triazine-2,4,6-tricarboxylic acid triethyl ester (4) with arylhydrazines provided 5-amino-6-oxo-1,6-dihydro[1,2,4]triazine-3- carboxylic acid ethyl esters 5a-g in moderate to good yields. Hydrolysis under basic conditions gave the corresponding free carboxylic acids 6a-d. Despite the relatively high number of heteroatoms present the amido as-triazine compounds 6a-d showed good solubility in phosphate buffer as determined by a lyophilization solubility assay. Building block 5a served as starting point for the syntheses of two discrete exocyclic 5-amido and 3-amido compound libraries 7 and 8, respectively.

sym-TRIAZINE DERIVATIVES. 8. STRUCTURE AND FURTHER REACTIONS OF PRODUCTS FORMED IN THE REACTION OF 2,4,6-TRIETHOXYCARBONYL-sym-TRIAZINE WITH ARYLHYDRAZINES

It has been demonstrated, based on detailed spectral analysis and chemical reaction studies, that the products of the reactions of arylhydrazines or semicarbazide with 2,4,6-triethoxycarbonyl-sym-triazine are 1,2,4-triazine derivatives.