127721-27-1

Basic information

• Product Name: [1,1'-Binaphthalene]-2-carboxylic acid, 2'-methoxy-, 1-methylethyl ester
• CAS NO: 127721-27-1
• Molecular Formula: C25H22O3
• Molecular Weight: 370.448
• Mol File: 127721-27-1.mol

Chemical Properties

• CAS DataBase Reference: [1,1'-Binaphthalene]-2-carboxylic acid, 2'-methoxy-, 1-methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Binaphthalene]-2-carboxylic acid, 2'-methoxy-, 1-methylethyl ester(127721-27-1)
• EPA Substance Registry System: [1,1'-Binaphthalene]-2-carboxylic acid, 2'-methoxy-, 1-methylethyl ester(127721-27-1)

Safety Data

• Hazardous Substances Data: 127721-27-1(Hazardous Substances Data)

Upstream product

• 546-68-9 titanium(IV) isopropylate 
• 80317-69-7 (aS)-2’-methoxy-(1,1’-binaphthyl)-2-carboxylic acid 
• 1745-81-9 o-Allylphenol 

Relevant articles and documents

Asymmetric hydroalkoxylation of non-activated alkenes: Titanium-catalyzed cycloisomerization of allylphenols at high temperatures

The asymmetric catalytic addition of alcohols (phenols) to non-activated alkenes has been realized through the cycloisomerization of 2-allylphenols to 2-methyl-2,3-dihydrobenzofurans (2-methylcoumarans). The reaction was catalyzed by a chiral titanium-carboxylate complex at uncommonly high temperatures for asymmetric catalytic reactions. The catalyst was generated by mixing titanium isopropoxide, the chiral ligand (aS)-1-(2-methoxy-1-naphthyl)-2-naphthoic acid or its derivatives, and a co-catalytic amount of water in a ratio of 1:1:1 (5 mol % each). This homogeneous thermal catalysis (HOT-CAT) gave various (S)-2-methylcoumarans with yields of up to 90 and in up to 85 e at 240°C, and in 87 ee at 220 °C.