127725-19-3Relevant academic research and scientific papers
Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration
Kwon, Yungeun,Wang, Qiu
, p. 4141 - 4145 (2020)
A copper-catalyzed aminocyanation of alkenes has been achieved through distal cyano migration using O-benzoylhydroxylamines and N-fluorobenzenesulfonimides. This method offers a rapid approach to generate diverse β-amino and β-sulfonimido nitriles. These reactions feature mild conditions, tolerance of sensitive functional groups, and excellent regioselectivity. Mechanistic studies suggest that these transformations are initiated by a copper-catalyzed amination step followed by a cyano migration step.
ENZYMATIC KINETIC RESOLUTION OF CYANOHYDRIN ACETATES AND ITS APPLICATION TO THE SYNTHESIS OF (S)-(-)-FRONTALIN
Ohta, Hiromichi,Kimura, Yoichi,Sugano, Yasushi,Sugai, Takeshi
, p. 5469 - 5476 (2007/10/02)
Kinetic resolution of racemic 1-cyano-1-methylalkyl and alkenyl acetates has been achieved on incubation with Pichia miso IAM 4682, which hydrolyzed selectively the (R)-enantiomer, leving behind the (S)-enantiomer intact.The chiral 1-cyano-1-methyl-5-hexenyl acetate thus obtained was converted to (S)-frontalin via unsaturated diol.
