127727-07-5Relevant academic research and scientific papers
Catalytic, Enantioselective α-Alkylation of Azlactones with Nonconjugated Alkenes by Directed Nucleopalladation
Nimmagadda, Sri Krishna,Liu, Mingyu,Karunananda, Malkanthi K.,Gao, De-Wei,Apolinar, Omar,Chen, Jason S.,Liu, Peng,Engle, Keary M.
, p. 3923 - 3927 (2019)
A palladium(II)-catalyzed enantioselective α-alkylation of azlactones with nonconjugated alkenes is described. The reaction employs a chiral BINOL-derived phosphoric acid as the source of stereoinduction, and a cleavable bidentate directing group appended to the alkene to control the regioselectivity and stabilize the nucleopalladated alkylpalladium(II) intermediate in the catalytic cycle. A wide range of azlactones were found to be compatible under the optimal reaction conditions to afford products bearing α,α-disubstituted α-amino-acid derivatives with high yields and high enantioselectivity.
A versatile and stereoselective synthesis of fnnctionalized cyclobutenes
Frebault, Frederic,Luparia, Marco,Oliveira, Maria Teresa,Goddard, Richard,Maulide, Nuno
supporting information; experimental part, p. 5672 - 5676 (2010/10/21)
(Figure Presented) Square flat: A new atom-economical method for the synthesis of functionalized cyclobutenes has been developed. This versatile sequence hinges upon a unique combination of an elegant photochemical isomerization and a palladium-catalyzed
