127732-98-3

Upstream product

• 6187-87-7 7-Aminocephalosporanic acid t-butyl ester 
• 58249-92-6 tert-butyl 3-(acetyloxymethyl)-7-diazo-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate 
• 63599-58-6 (6R)-3-acetoxymethyl-7c-hydroxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 701-99-5 Phenoxyacetyl chloride 

Downstream Products

• 127733-04-4 (6R,7S)-3-Acetoxymethyl-5,5,8-trioxo-7-(2-phenoxy-acetoxy)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

Time-dependent inhibitors of the enzyme human leukocyte elastase have been developed based on the cephem nucleus. A series of cephalosporin tert-butyl esters has been examined, and the activity of these compounds has been found to be very sensitive to C-7

Process for preparing 7-oxo cephalosporins and 6-oxo penicillins

A process for preparing 7-oxo cephalosporins and 6-oxo penicillins by reaction of a 7-amino cephalosporin or 6-amino penicillin with a carbonyl-containing oxidizing agent is disclosed.