127747-07-3

Basic information

• Product Name: 1,1-di(2-methanesulfonyloxyethyl)cyclohexane
• Synonyms: 1,1-di(2-methanesulfonyloxyethyl)cyclohexane
• CAS NO: 127747-07-3
• Molecular Weight: 328.451
• Mol File: 127747-07-3.mol

Chemical Properties

• CAS DataBase Reference: 1,1-di(2-methanesulfonyloxyethyl)cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-di(2-methanesulfonyloxyethyl)cyclohexane(127747-07-3)
• EPA Substance Registry System: 1,1-di(2-methanesulfonyloxyethyl)cyclohexane(127747-07-3)

Safety Data

• Hazardous Substances Data: 127747-07-3(Hazardous Substances Data)

Upstream product

• 3187-27-7 2,2'-(cyclohexane-1,1-diyl)bis(ethan-1-ol) 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1070768-58-9 1,1-di(2-selenocyanatoethyl)cyclohexane 
• 1070768-57-8 1,1-di(2-thiocyanatoethyl)cyclohexane 
• 4375-49-9 3-benzyl-3-azaspiro[5.5]undecane 

Relevant articles and documents

Macrocyclic cyclophanes with two and three α,ω-dichalcogena-1, 4-diethynylaryl units: Syntheses and structural properties

(Chemical Equation Presented) By means of four- and six-component cyclization reaction various cyclophanes were synthesized. The components were the di(lithium) salts of 1,4-di(ethynyl)benzene (11), 4,4′-di(ethynyl) biphenyl (13), 1,4-di(ethynyl)-2,5-di(n-hexyl)benzene (18), and 1,4-di(ethynyl)-2,5-di(n-propyl)benzene (19). These building blocks were reacted with α,ω-dithiocyanato-n-alkanes and α,ω- diselenocyanato-n-alkanes with n = 3-6. In the case of 10 also 1,1′-di(2-thiocyanatoethyl)cyclohexane (24) was reacted to afford a cyclophane comprising three subunits of 11. From most of the resulting macrocyclic cyclophanes (4(n) (n = 3, 5), 5, 6, 7(n), 8(n) (n = 3-6), 9(n) (n = 3, 5), and 10), we were able to grow single crystals. The X-ray analysis of 4(3), 7(3), 8(3), 8(4), 6, 7(5), and 8(5) revealed close contacts between the chalcogen atoms. These chalcogen-chalcogen interactions impose a ribbon-shape arrangement of molecules in 4(3) and a mutual crossing of two perdendicular planes built of 8(4) molecules. For 4(3) we found a close contact (3.28 A) between the π planes of two neighboring C6H4 rings of different molecules, whereas in 8(4) such a close contact (3.74 A) was due to an intermolecular interaction. Tubular stacking of the macrocyclic rings was found for 7(5) and 8(5) caused by a ladder-type intermolecular chalcogen-chalcogen interaction.

SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF

The present invention relates to a CXCR3 antagonist comprising a compound represented by formula (I) (wherein all the symbols have the same meaning as defined in the description), a salt thereof, a quaternary ammonium salt thereof, an N-oxide form thereof or a solvate thereof, or a prodrug thereof. This antagonist is useful as a preventive, therapeutic and/or progression-suppressing agent for a CXCR3-mediated disease such as an immune or an allergic disease [e.g., an atopic disease, an autoimmune disease (e.g., multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, glomerulonephritis, Sjogren's syndrome and the like), systemic inflammatory response syndrome (SIRS), a rejection response to transplanted organ, tissue and/or cell or the like], a gastrointestinal disease [e.g., an inflammatory bowel disease or the like], or a respiratory disease [e.g., asthma, a chronic obstructive pulmonary disease or the like].