127749-73-9Relevant academic research and scientific papers
Synthesis of novel heterocyclic compounds incorporate 4,5,6,7-tetrahydrobenzo[b]thiophene together with their cytotoxic evaluations
Abdallah, Amira Elsayed Mahmoud,Mohareb, Rafat Milad,Khalil, Eid Metwally,Elshamy, Menna Alla Mohamed Abd Elaleem
, p. 469 - 477 (2017)
The 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene was the key starting compound used to synthesize new thiazole, pyrimidine, pyran, pyridine and thiazine derivatives. The cytotoxicity of the synthesized compounds was studied towards the three cancer cell lines namely MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (central nervous system (CNS) cancer) in addition to the normal cell line (WI-38) using doxorubicin as the reference drug. The study showed that compounds 5, 9a, 15b, 17c, 18 and 21b were the most potent compounds.
Synthesis, Antitumor and Anti-HIV-1 Testing of Certain Thieno[2,3-d]pyrimidine, Thieno[2,3-d]imidazo[1,2-c] pyrimidine and Thieno[2,3-d][1,3]thiazine Derivatives
Shehata,El-Subbagh,Abdelal,El-Sherbeny,Al-Obaid
, p. 148 - 163 (2007/10/03)
A series of tetrahydrobenzo[b]thieno[2,3-d]pyrimidines, thieno[3,2-e]imidazo[1,2-c]pyrimidines and thieno[2,3-dt][1,3]thiazines was synthesized as antitumor, antiviral agents. Compounds 2, 3 and 17 possessed moderate Anti-HIV-1 potency with EC50 values ranging from 1.83 × 10-5 to 3.42 × 10-5 molar concentrations. All of the tested compounds showed cytotoxic effects (log GI50 ≤ -4.0) against the growth of a variety of human tumor cell lines, including those derived from solid tumors. Compounds 3 and 7 showed strong potency while compounds 11 and 16 exhibited moderate activity. The detailed synthesis, spectroscopic and biological data are reported.
