127749-73-9

Basic information

• Product Name: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N'-phenylthiourea
• Synonyms: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N'-phenylthiourea
• CAS NO: 127749-73-9
• Molecular Formula: C₁₆H₁₅N₃S₂
• Molecular Weight: 313.4404
• Mol File: 127749-73-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N'-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N'-phenylthiourea(127749-73-9)
• EPA Substance Registry System: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-N'-phenylthiourea(127749-73-9)

Safety Data

• Hazardous Substances Data: 127749-73-9(Hazardous Substances Data)

Upstream product

• 4651-91-6 3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene 
• 103-72-0 phenyl isothiocyanate 
• 108-94-1 cyclohexanone 

Downstream Products

• 38201-60-4 4-oxo-2-thioxo-1,2,3,4,5,6,7,8-octahydrobenzothieno<2,3-d>pyrimidine 
• 127749-75-1 4-anilino-2-thioxothieno<2.3-d>pyrimidine 

Relevant articles and documents

Synthesis of novel heterocyclic compounds incorporate 4,5,6,7-tetrahydrobenzo[b]thiophene together with their cytotoxic evaluations

The 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene was the key starting compound used to synthesize new thiazole, pyrimidine, pyran, pyridine and thiazine derivatives. The cytotoxicity of the synthesized compounds was studied towards the three cancer cell lines namely MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (central nervous system (CNS) cancer) in addition to the normal cell line (WI-38) using doxorubicin as the reference drug. The study showed that compounds 5, 9a, 15b, 17c, 18 and 21b were the most potent compounds.

Synthesis of 4-arylamino-thioxothieno [2,3-d] pyrimidines

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