127757-40-8

Basic information

• Product Name: (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine
• Synonyms: (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine
• CAS NO: 127757-40-8
• Molecular Weight: 591.664
• Mol File: 127757-40-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine(127757-40-8)
• EPA Substance Registry System: (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine(127757-40-8)

Safety Data

• Hazardous Substances Data: 127757-40-8(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 58274-10-5 4-amino-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrimidin-2-one 
• 127757-42-0 N-[1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 127757-35-1 1-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-4-methoxy-1H-pyrimidin-2-one 
• 55559-70-1 1-(S)-(2,3-dihydroxypropyl)cytosine 
• 26661-13-2 4-N-benzoylcytosine 
• 834906-31-9 (S)-glycidyl 4,4’-dimethoxytrityl ether 
• 62853-19-4 (S)-N-(1-(2,3-dihydroxypropyl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide 
• 127757-41-9 N-[3-Benzoyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-2-oxo-2,3-dihydro-1H-pyrimidin-(4E)-ylidene]-benzamide 

Downstream Products

• 127785-75-5 Benzoic acid (S)-1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester 
• 120362-37-0 disodium salt of 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine 
• 916599-37-6 acetic acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethyl ester 
• 916599-36-5 acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester 

Relevant articles and documents

P-Stereodefined phosphorothioate analogs of glycol nucleic acids—synthesis and structural properties

Enantiomerically pure, protected acyclic nucleosides of the GNA type (glycol nucleic acids) (GN′), obtained from (R)-(+)- and (S)-(?)-glycidols and the four canonical DNA nucleobases (Ade, Cyt, Gua and Thy), were transformed into 3′-O-DMT-prote

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Synthesis of propane-2,3-diol combinatorial monomers

Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroaryl-propane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis.