12777-70-7 Usage
Biological Activity
Dryocrassin is a flavonoid natural product, a phloroglucinol derivative derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. Biological and pharmacological activities of dryocrassin have attracted attention. Dryocrassin exhibits antiviral activity against H5N1 avian influenza virus. Dryocrassin inhibits the coagulase activity of Staphylococcus aureus vWbp. Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.
Check Digit Verification of cas no
The CAS Registry Mumber 12777-70-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,7,7 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 12777-70:
(7*1)+(6*2)+(5*7)+(4*7)+(3*7)+(2*7)+(1*0)=117
117 % 10 = 7
So 12777-70-7 is a valid CAS Registry Number.
InChI:InChI=1/C43H48O16/c1-9-11-24(46)28-32(50)18(30(48)20(34(28)52)14-22-36(54)26(16(3)44)40(58)42(5,6)38(22)56)13-19-31(49)21(35(53)29(33(19)51)25(47)12-10-2)15-23-37(55)27(17(4)45)41(59)43(7,8)39(23)57/h48-57H,9-15H2,1-8H3
12777-70-7Relevant articles and documents
Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases
Hou, Bo,Liu, Ze,Yang, Xiao-Bei,Zhu, Wen-Fei,Li, Jin-Yu,Yang, Liu,Reng, Fu-Cai,Lv, Yong-Feng,Hu, Jiang-Miao,Liao, Guo-Yang,Zhou, Jun
, p. 3846 - 3852 (2019)
The stems of Dryopteris crassirhizoma, one of the main components of Lianhua-Qingwen Formula (LQF) was traditionally used for heat-clearing and detoxifying. Dryocrassin ABBA is a key antiviral component in the herbal medicine while the compound is hard to