127820-18-2Relevant academic research and scientific papers
Direct N9-arylation of purines with aryl halides
Larsen, Anders Foller,Ulven, Trond
supporting information, p. 4997 - 4999 (2014/05/06)
An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N
Copper-mediated N-arylation in the synthesis of aryladenines
Krouzelka, Jan,Linhart, Igor
experimental part, p. 1205 - 1216 (2009/11/30)
A series of N3 and N9 aryladenines was prepared by arylation of 8-bromoadenine under modified Chan-Lam-Evans coupling conditions followed by reductive debromination with hydrogen on palladium. Conditions of arylation were optimised to maximise the yield o
A mild and efficient method for N-arylnucleobase synthesis via the cross-coupling reactions of nucleobases with arylboronic acids catalyzed by simple copper salts
Tao, Lan,Yue, Yang,Zhang, Ji,Chen, Shan-Yong,Yu, Xiao-Qi
scheme or table, p. 1008 - 1014 (2009/02/07)
A simple and efficient copper-salt catalyzed N-arylation of nucleobases is reported. In a mixed solvent of MeOH and H2O, the coupling products were obtained in moderate to excellent yields at room temperature within a short time. Avariety of su
Purine Derivatives as Competitive Inhibitors of Human Erythrocyte Membrane Phosphatidylinositol 4-Kinase
Young, Rodney C.,Jones, Martin,Milliner, Kevin J.,Rana, Kishore K.,Ward, John G.
, p. 2073 - 2080 (2007/10/02)
The possibility of deriving a potent, cell-penetrating inhibitor of human erythrocyte PI 4-kinase, competitive with respect to ATP, has been investigated in a series of purine derivatives and analogues.The purine nucleus is not essential for binding to th
