6974-78-3Relevant articles and documents
A self-complementary nucleoside: Synthesis, solid-state structure, and fluorescence behavior
Bang, Eun-Kyoung,Won, Jiyeon,Moon, Dohyun,Lee, Jin Yong,Kim, Byeang Hyean
, p. 2048 - 2054 (2011)
A novel self-complementary nucleoside (AT), featuring two complementary nucleobases linked through an ethynyl group has been synthesized. The rigid aromatic nucleobases provided AT with a pale-blue fluorescence. Unlike most fluorescent organic molecules, nucleoside AT gives enhanced fluorescence in solid state. It exhibits considerably enhanced fluorescence intensity and a remarkable redshift (ca. 70 nm) in its emission maximum upon an increase in concentration or decrease in temperature as a result of the formation of aggregates stabilized through hydrogen bonding and π-π stacking of well-organized AT assemblies; these interactions are also evident in the solid-state structure, determined by X-ray crystallography. DFT calculations supported the preference of such aggregation processes.
INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF
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Paragraph 00236; 00245, (2021/01/23)
Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of LMPTP, compositions, and methods of using these compounds and compositions.
Protease inhibitors (by machine translation)
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Paragraph 0023; 0036; 0037; 0038, (2018/09/28)
The invention relates to a Grp94 specific Hsp - 90 inhibitor, a protease inhibitor of the preparation method, to solve the existing problems on the preparation method of the blank defect, comprising the following processing steps: in the three flasks, is put into the water-free of dimethyl formamide, under the protection of nitrogen, adding 3, 5 - dichloro dithiol, completely dissolved after stirring, then slowly adding sodium hydride, stirring at room temperature the reaction 1 hours; then and then adding 8 - bromo - 9 - (3 - isopropylamino) propyl adenine, after adding gradually raising the temperature to 150 degrees, reflux reaction for 6 hours; after the reaction is complete cooling to room temperature, the reaction liquid is slowly added to the water, quenching the unreacted sodium hydride, methylene chloride/methanol mixed solution extraction, the organic phase is used for the saturated salt water and saturated ammonium chloride solution washing several times, and then after the saturated sodium bicarbonate multi-time extraction, for water-free magnesium sulfate drying, steaming and, for column chromatography column purification. (by machine translation)
