127825-08-5Relevant academic research and scientific papers
MIXED CARBOXYLIC - CARBONIC ANHYDRIDE METHOD IN PHOSPHONO PEPTIDE SYNTHESIS
Kafarski, Pawel,Lejczak, Barbara
, p. 7387 - 7396 (1989)
Factors influencing the reaction yields and formation of the side products during coupling of N-carbobenzoxyamino acids with dialkyl or diphenyl aminoalkylphosphonates, by means of mixed anhydryde procedure, were evaluated.The recommended procedure, arising from these studies, involves the use of chloroform/ethyl chloroformate/triethylamine system and delicate warming of the reaction mixture during the coupling step.
