MIXED CARBOXYLIC - CARBONIC ANHYDRIDE METHOD IN PHOSPHONO PEPTIDE SYNTHESIS

DOI: 10.1016/S0040-4020(01)89200-0

Source and publish data:

Tetrahedron p. 7387 - 7396 (1989)

Update date:2022-07-30

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Authors:

Kafarski, Pawel

Lejczak, Barbara

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Article abstract of DOI:10.1016/S0040-4020(01)89200-0

Factors influencing the reaction yields and formation of the side products during coupling of N-carbobenzoxyamino acids with dialkyl or diphenyl aminoalkylphosphonates, by means of mixed anhydryde procedure, were evaluated.The recommended procedure, arising from these studies, involves the use of chloroform/ethyl chloroformate/triethylamine system and delicate warming of the reaction mixture during the coupling step.

Full text of DOI:10.1016/S0040-4020(01)89200-0

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