MIXED CARBOXYLIC - CARBONIC ANHYDRIDE METHOD IN PHOSPHONO PEPTIDE SYNTHESIS

DOI: 10.1016/S0040-4020(01)89200-0

Source and publish data:

Tetrahedron p. 7387 - 7396 (1989)

Update date:2022-07-30

Topics:

Authors:

Kafarski, Pawel

Lejczak, Barbara

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)89200-0

Factors influencing the reaction yields and formation of the side products during coupling of N-carbobenzoxyamino acids with dialkyl or diphenyl aminoalkylphosphonates, by means of mixed anhydryde procedure, were evaluated.The recommended procedure, arising from these studies, involves the use of chloroform/ethyl chloroformate/triethylamine system and delicate warming of the reaction mixture during the coupling step.

Full text of DOI:10.1016/S0040-4020(01)89200-0

Products guided by the article

Product name:diphenyl <1-N-benzyloxycarbonyl-L-leucylamino(4-methoxyphenyl)>methylphosphonate

Cas No:127825-08-5

R&D Labs maybe for 127825-08-5

Shanghai Rlavie Technology Co., Ltd.

website:http://www.rlavie.com

Contact:021-67759270

Address:1 Floor, No.1990 Jinbi Road, Fengxian District, Shanghai
Nantong Chem-land Co., Ltd.

Contact:86 513 85512619

Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China
Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi
LinHai Cina Chemical Co., LTD.

Contact:0576-85580989

Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI

Relevant to this article

CATALYTIC PHOSPHORYLATION OF POLYFLUOROALKANOLS. 14. SYNTHESIS AND DIASTEREOMERIC CONVERSION OF ARYL(α-POLYFLUOROALKYLBENZYL) CHLOROPHOSPHATES

Doi:10.1007/BF00960671
(1990)
Wittig-Horner reaction of dimethyl phthalide-3-phosphonates with ketones: Synthesis of 3-ylidenephthalides and their conversion to 2,2-disubstituted indan-1,3-diones including spirocyclic compounds

Doi:10.1055/s-1994-25642
(1994)
Stereoselective total synthesis of (+)-oploxyne A, (-)-oploxyne B, and their C-10 epimers and structure revision of natural oploxyne B

Doi:10.1021/jo102445h
(2011)
Intra- and intermolecular nucleophilic phosphorus - sulfur bond cleavage. The reaction of fluoride ion with O-aryl-O,S-dialkylphosphorothioates, and the degradation of phosphorothioate linkage in di-ribonucleotides by the vicinal 2'-hydroxyl group

Doi:10.1016/S0040-4020(01)89215-2
(1989)
Protocol for the synthesis of heteroaromatic ring-Fused cyclohexanones

Doi:10.1021/ol200305n
(2011)
A Case of Highly Diastereoselective Addition to Unsymmetrical Ketones: lk-Addition of (2-Alkenyl)triphenoxytitanium Derivatives

Doi:10.1002/hlca.19820650704
(1982)

Article Doi