127865-40-1

Upstream product

• 870-23-5 prop-2-ene-1-thiol 
• 75-52-5 nitromethane 
• 123-11-5 4-methoxy-benzaldehyde 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 

Downstream Products

• 127865-51-4 6-(4-methoxyphenyl)-3,3a,4,6-tetrahydrothiopheno<3,4-c>isoxazole 
• 128869-59-0 cis-3-amino-4-(hydroxymethyl)-trans-2-(4-methoxyphenyl)tetrahydrothiophene 
• 128869-60-3 3-(hydroxymethyl)-1-(4-methoxyphenyl)-2-butanone 
• 127865-46-7 6-(4-methoxyphenyl)-3,3a,4,6-tetrahydrothiopheno<3,4-c>isoxazole 

Relevant academic research and scientific papers

A theoretical evaluation of the Michael-acceptor ability of conjugated nitroalkenes

A theoretical evaluation of the relative Michael-acceptor abilities of a variety of substituted aromatic and aliphatic nitroalkenes is reported. Several global and local reactivity indices were evaluated with the incorporation of natural charge obtained f

Pesticidal and parasiticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds

The present invention relates to the pesticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds having the structural formula I

Pesticidal and parasiticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds

The present invention relates to the pesticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds having the structural formula I

One-pot synthesis of five-membered cyclic thioethers or ethers via intramolecular nitrile oxide-olefin cycloaddition (INOC) or intramolecular alkoxycarbonyl nitronate-olefin cycloaddition (IAOC) by the use of methyl chloroformate

Reaction of β-nitrostyrenes 1 with allyl mercaptan 2 in the presence of triethylamine generated unsaturated nitro sulfides 3 and then the solution was treated with methyl chloroformate (MCF) and was refluxed to obtain [3.3.0]bicyclic products trans-6 and cis-6 in one-pot. The ratios of trans- 6:cis-6 were from 1.1:1 to 1.8:1 and the mechanism of the formation 6 is proposed to proceed through the formation of nitrile oxides 5 to undergo intramolecular nitrile oxide-olefin cycloaddition (INOC). Nitronates 16, prepared from 1 with allyl alcohol and base, can be converted into methoxycarbonyl nitronates 22 by treating the solution with methyl chloroformate and catalytic amount of 4-dimethylaminopyridine (DMAP) in the presence of different amounts of triethylamine. Intermediates 22 can either undergo intramolecular alkoxycarbonyl nitronate-olefin cycloaddition (IAOC) to generate highly stereoselective product trans-14 or undergo INOC to yield trans-14 and cis-14. The application of this improved methodology to synthesize different heterocyclic products 10, 26, and 27 is reported.

A Two-Step Conversion of Carbonyl Compounds into Functionalized Five- and Six-Membered Ring Thioethers via Intramolecular Cycloaddition

Reaction of aldehydes or ketones with nitromethane in the presence of unsaturated thiols led directly to unsaturated nitro sulfides 7, 12, 14, or 19.These compounds were converted by intramolecular nitrile oxide-olefin cycloaddition to tetrahydrothiopheno