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Potential GABAB Receptor Antagonists. VI. The Synthesis of Saclofen and Other Sulfonic Acid Derivatives
Abbenante, Giovanni,Prager, Rolf H.
, p. 1801 - 1810 (2007/10/02)
Saclofen, 3-amino-2-(4-chlorophenyl)propanesulfonic acid (3), has been synthesized by two routes.Attempts to hyrogenolyse or dehydrate the 2-hydroxy derivative were unsuccessful, however.Radical sulfonation of 3-amino-1-bromo-2-(4-chlorophenyl)propene gav
