127876-37-3

Basic information

• Product Name: 2-(2H-benzo[d][1,2,3]triazol-2-yl)-1-phenylethan-1-one
• Synonyms: 2-(2H-benzo[d][1,2,3]triazol-2-yl)-1-phenylethan-1-one
• CAS NO: 127876-37-3
• Molecular Weight: 237.261
• Mol File: 127876-37-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(2H-benzo[d][1,2,3]triazol-2-yl)-1-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2H-benzo[d][1,2,3]triazol-2-yl)-1-phenylethan-1-one(127876-37-3)
• EPA Substance Registry System: 2-(2H-benzo[d][1,2,3]triazol-2-yl)-1-phenylethan-1-one(127876-37-3)

Safety Data

• Hazardous Substances Data: 127876-37-3(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 70-11-1 α-bromoacetophenone 
• 3282-32-4 2-diazo-acetophenone 
• 93-91-4 1-phenylbutan-1,3-dione 
• 532-27-4 1-chloroacetophenone 
• 15217-42-2 sodium benzotriazolate 

Downstream Products

• 187242-30-4 4-Benzotriazol-2-yl-5-oxo-5-phenyl-pentanoic acid ethyl ester 
• 187242-31-5 4-Benzotriazol-2-yl-5-oxo-5-phenyl-pentanoic acid 
• 187242-38-2 5-Benzotriazol-2-yl-1,6-diphenyl-3,4-dihydro-1H-pyridin-2-one 
• 187242-39-3 5-Benzotriazol-2-yl-6-phenyl-1-p-tolyl-3,4-dihydro-1H-pyridin-2-one 

Relevant articles and documents

Rhodium-Catalyzed Regioselective N2-Alkylation of Benzotriazoles with Diazo Compounds/Enynones via a Nonclassical Pathway

A novel rhodium-catalyzed highly selective N2-alkylation of benzotriazoles with diazo compounds/enynones is achieved, providing N2-alkylated benzotriazoles in good to excellent yields and with excellent N2 selectivities. Importantly, different to traditional carbene insertion into X?H (X=N, O etc) bonds, DFT calculations disclose that this selective N2-alkylation probably proceeds through a formal 1,3- rather than 1,2-H shift to give the final products.

Green and efficient protocol for N-alkylation of benzotriazole using basic ionic liquid [Bmim]OH as catalyst under solvent-free conditions

N-Alkylation of benzotriazole bearing an acidic hydrogen atom attached to nitrogen with alkyl halides is accomplished in basic ionic liquid [Bmim]OH (1-butyl-3-methylimidazolium hydroxide) under solvent-free conditions. The procedure is convenient and efficient and generally affords the N-alkylated product. Taylor & Francis Group, LLC.

Aqueous micellar medium in organic synthesis: Alkylations and Michael reactions of benzotriazole

The feasibility of aqueous micelles of cetyltrimethylammonium bromide in catalyzing C-N bond formation has been studied with respect to N-alkylations of benzotriazole (Bt). Alkylations with various alkylating agents and the addition of Bt across activated double bonds in the Michael fashion occurred successfully in fair-to-good yields in the aqueous micellar regime. These reactions provided a mixture of N-1 and N-2 alkylated products, with a marked preference for N-1 over N-2 isomers. Micellar catalysis has been evaluated experimentally to indicate over a 50% micellar contribution to these alkylations in contrast to their aqueous counterparts. Since, N-alkyl benzotriazoles are of potential biological interest, the present micellar procedure offers a convenient alternative to other available methods.