127876-41-9Relevant academic research and scientific papers
Azolyacetones as precursors to indoles and naphthofurans facilitated by microwave irradiation with simultaneous cooling
Al-Mousawi, Saleh Mohammed,El-Apasery, Morsy Ahmed
, p. 2976 - 2984 (2009)
Phthalimide reacted with phenacyl bromide under microwave irradiation to yield phenacyl isoindolidene-1,3-dione (3b), while 3a reacted with phenylhydrazine to yield the phenylhydrazone 4 that was readily converted into indoylphthalimide 8. Similarly N-benzotriazolylacetone (6a) reacted with phenyl hydrazine to yield the phenylhydrazone 7a that was converted into indoylbenzotriazole 9. Treatment of 8 with hydrazine hydrate afforded a mixture of phthalhydrazide 10 and 3-amino-2-methylindole (11). Reacting enaminone 13 with naphthoquinone (14) afforded the aryl naphthofuran 17. The possibility of the formation of the aldehyde 18 was excluded based on HMQC, which revealed that the carbonyl carbon is not linked to any hydrogen.
Structure-cytotoxicity relationship of a novel series of miconazole-like compounds
Yousefi, Reza,Khalafi-Nezhad, Ali,Panahi, Farhad,Soltani Rad, Mohammad Navid,Behrouz, Somayeh,Esmaili, Mansoore,Ghaffari, Sayed Mahmoud,Moosavi-Movahedi, Ali Akbar,Niazi, Ali
, p. 1921 - 1928,8 (2020/07/30)
In the current study, two novel classes of the carboacyclic nucleosides having miconazole-like scaffolds as imidazole- and pyrimidine-based compounds were examined for their cytotoxic properties. The aim was to establish a relation between cytotoxic activ
The Formation of Ketones by a Reaction Equivalent to R- + R'COCH2+ -> R'COCH2R
Katritzky, Alan R.,Wrobel, Leszek,Savage, G. Paul,Deyrup-Drewniak, Malgorzata
, p. 133 - 139 (2007/10/02)
A general method has been developed for the overall transformation of α-bromo ketones to α-alkyl or α-aryl ketones, with benzotriazole being used as a synthetic auxiliary, α-Benzotriazolyl ketones, when converted into their phenylhydrazones, reacted smoothly with alkyl and aryl Grignard reagents, which displaced benzotrazolate, to give the corresponding α-alkyl and α-aryl hydrazones.In some cases, these hydrolysed directly to the α-alkyl or α-aryl ketones.In each case, the product was treated with 2,4-dinitrophenylhydrazine to isolate the target ketones as the corresponding 2,4-dinitrophenylhydrazones.
