127895-99-2

Basic information

• Product Name: N-<(4-Methylphenyl)methylene>-2-methyl-2-propanamine N-oxide
• CAS NO: 127895-99-2
• Molecular Weight: 191.273
• Mol File: 127895-99-2.mol

Chemical Properties

• CAS DataBase Reference: N-<(4-Methylphenyl)methylene>-2-methyl-2-propanamine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-<(4-Methylphenyl)methylene>-2-methyl-2-propanamine N-oxide(127895-99-2)
• EPA Substance Registry System: N-<(4-Methylphenyl)methylene>-2-methyl-2-propanamine N-oxide(127895-99-2)

Safety Data

• Hazardous Substances Data: 127895-99-2(Hazardous Substances Data)

Upstream product

• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 104-87-0 4-methyl-benzaldehyde 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 594-70-7 2-Methyl-2-nitropropane 
• 86401-98-1 N-(tert-butyl)-N-(4-methyl-benzylidene)-amine 

Downstream Products

• 1346238-44-5 (E)-N-(3-(cyclohex-1-en-1-yl)-1-(p-tolyl)prop-2-yn-1-ylidene)-2-methylpropan-2-amine oxide 
• 69305-71-1 C₁₂H₁₈NO 
• 141080-63-9 C₁₂H₁₈NO₃ 
• 141080-54-8 C₁₂H₁₈NO₂ 
• 16649-50-6 N-tert-Butylhydroxylamine 
• 104-87-0 4-methyl-benzaldehyde 
• 135485-48-2 C₁₉H₂₈NO₃ 
• 54078-56-7 C₁₈H₂₂NO 
• 135485-59-5 C₁₉H₂₂NO₃ 

Relevant articles and documents

N-tert-Butyl and N-methyl nitrones derived from aromatic aldehydes inhibit macromolecular permeability increase induced by ischemia/reperfusion in hamsters

N-Alquil nitrones 1c and 3-6 were prepared from aromatic aldehydes and N-tert-butylhydroxylamine or N-methylhydroxylamine in good yields and soft conditions. Their protective effect against microvascular damages caused by ischemia/reperfusion in 'hamster

Chromium and Tungsten Pentacarbonyl Groups as Reactivity and Selectivity Auxiliaries in Cycloaddition of Alkynyl Fischer Carbene Complexes with N-Alkyl Nitrones

Alkynyl Fischer carbene complexes were found to undergo chemoselective, regioselective, and rate-enhanced 1,3-dipolar cycloaddition with nitrones to give 2,3-dihydroisoxazole carbene complexes in excellent yields.These alkynyl complexes can serve as synth

Synthesis and Characterization of Phenyl-Substituted C-Phenyl-N-tert-butylnitrones and Some of Their Radical Adducts

Synthesis of C-phenyl-N-tert-butylnitrone (PBN) and several of its analogues with substituents in the 2-, 3-, or 4-position on the phenyl ring is described.While a one-pot reduction/condensation method proved suitable for the most compounds, it was necessary to prepare some examples by direct condensation or through oxidation of the appropriate imine.The 1H NMR data for the 3-X- and 4-X-PBN's can be correlated with the Hammett equation.For the 3-X series Δδ for the α-proton correlates best with ?+ and has a correlation coefficient of 0.90.For the 4-X series a dual substituent parameter equation using ?R0 gives the best correlation with r = 0.99.The hyperfine splitting constants (hfsc's) of HO and HOO adducts of serveral substituted PBN's are also included and their correlation with the Hammett equation is discussed.

Imines and Derivatives. Part 24. Nitrone Synthesis by Imine Oxidation using either a Peroxyacid or Dimethyldioxirane

The oxidation of N-alkyl imines by m-chloroperoxybenzoic acid to yield nitrones was facilitated by (i) the presence of C-aryl substituents, (ii) steric inhibition of attack at the imino C-atom, (iii) electron donating para-substituents on the C-aryl substituent, (iv) non-hydroxylic solvents, (v) optimal conjugation between C-aryl substituents and the imino group, and (vi) less bulky N-alkyl groups. The oxidation of N-alkyl imines by dimethyldioxirane (DMD) in dichloromethane-acetone solution yielded nitrones without evidence of oxaziridine formation.The yields of isolated nitrones were higher for C,C-diaryl imines and for imines bearing less bulky N-alkyl substituents.N-H substituted ketimines were found to yield oximes after reaction with dimethyldioxirane.