127897-27-2Relevant academic research and scientific papers
Asymmetric Synthesis of Pipecolic Acid Derivatives Using the Aza-Diels-Alder Reaction
Bailey, Patrick D.,Brown, George R.,Korber, Fritjof,Reed, Amanda,Wilson, Robert D.
, p. 1263 - 1282 (2007/10/02)
Imines of the type R-N=CHCO2Et can be coerced into undergoing a (4+2) cycloaddition with substituted dienes if the reaction is carried out in DMF in the presence of both water and acid; these reactions show extremely high regio- and diastereoselectivity.U
Stereoselective synthesis of pipecolic acid derivatives using a aza-Diels-Alder reactions
Bailey,Wilson,Brown
, p. 6781 - 6784 (2007/10/02)
Pipecolic acid derivatives can be prepared by the aza-Diels-Alder reaction of dienes with the iminium salt derived from benzylamine and ethyl glyoxylate in DMF; the presence of a catalytic quantity of water is essential, and acyclic dienes react with high regio- and diastereoselectivity.
