1279082-46-0Relevant academic research and scientific papers
Catalytic asymmetric conjugate addition of Grignard reagents to coumarins - Synthesis of versatile chiral building blocks
Teichert, Johannes F.,Feringa, Ben L.
, p. 2679 - 2681 (2011)
A new protocol for the Cu-catalysed asymmetric conjugate addition of Grignard reagents to coumarins has been developed. The corresponding products are formed in high yields and enantioselectivities. Through a sequential protocol involving conjugate addition followed by nucleophilic ring opening of the chiral enolate, chiral esters and amides are readily accessible.
