1279083-87-2Relevant academic research and scientific papers
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes
Qian, Yimin,Wertheimer, Stanley J.,Ahmad, Mushtaq,Cheung, Adrian Wai-Hing,Firooznia, Fariborz,Hamilton, Matthew M.,Hayden, Stuart,Li, Shiming,Marcopulos, Nicholas,McDermott, Lee,Tan, Jenny,Yun, Weiya,Guo, Liang,Pamidimukkala, Anjula,Chen, Yingsi,Huang, Kuo-Sen,Ramsey, Gwendolyn B.,Whittard, Toni,Conde-Knape, Karin,Taub, Rebecca,Rondinone, Cristina M.,Tilley, Jefferson,Bolin, David
, p. 2433 - 2446 (2011/06/17)
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain on hig
