2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

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Chemical Name:2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide
CAS No.:1279083-87-2
Molecular Formula:C₂₁H₂₁F₃N₄O₃
Molecular Weight:434.418
Hs Code.:

Synonyms:2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

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Chemical Property of 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

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Technology Process of 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

There total 4 articles about 2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 939375-07-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}amide

: 74-88-4
methyl iodide

: 1279083-87-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm101580m

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1279083-87-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: 5% Pd(II)/C(eggshell); hydrogen / tetrahydrofuran; methanol / 1 h

3: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

4: sodium hydride / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; sodium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101580m

Reference yield:

: 1279083-88-3
N-(2-methoxyethyl)-N-methyl-5-nitropyridin-2-amine

: 1279083-87-2
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 5% Pd(II)/C(eggshell); hydrogen / tetrahydrofuran; methanol / 1 h

2: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

3: sodium hydride / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; sodium hydride; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101580m