127910-62-7

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 127811-91-0 (1R,5S,6S)-6-(1,3-dithian-2-yl)-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane 
• 127811-88-5 (4S,5R)-4-(1,3-dithian-2-ylidenemethyl)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane 
• 127811-92-1 tert-butyl (1R,5S,6S)-6-(1,3-dithian-2-yl)-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane-7-carboxylate 
• 127811-90-9 (3aR,6aS)-6-[1,3]Dithian-2-yl-2,2-dimethyl-4,6a-dihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole 
• 189996-60-9 2,3-O-isopropylidene-D-erythrose 
• 127910-61-6 (1R,5S,6S)-tert-butyl 6-formyl-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane-7-carboxylate 
• 144498-68-0 Toluene-4-sulfonic acid (4R,5S)-5-[1,3]dithian-2-ylidenemethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 

Downstream Products

• 144541-71-9 (2S,3S,4R)-3,4-dihydroxyproline trifluoroacetic acid salt 
• 95341-65-4 (2S,3S,4R)-3,4-dihydroxy-L-proline 

Relevant academic research and scientific papers

Ketene S,S-Acetals as 1,3-Dipolarophiles: Application to the Synthesis of Polyhydroxylated Pyrrolidines

Two approaches to the synthesis of the hydroxylated pyrrolidines 3 and 4, based on exploiting the reactivity of a ketene S,S-acetal as a 1,3-dipolarophile, are described.Both routes utilize a carbohydrate starting material and the strategy based on D-eryt

Ketene Dithioacetals as 1,3-Dipolarophiles. Applications to the Synthesis of Cyclic Amino Acids

Intramolecular azide cycloaddition reactions of ketene dithioacetals provide a new route to cyclic amino acids and a stereoselective synthesis of (2S,3S,4R)-3,4-dihydroxyproline (14) based on this methodology is described.