144498-68-0

Upstream product

• 127811-88-5 (4S,5R)-4-(1,3-dithian-2-ylidenemethyl)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane 
• 98-59-9 p-toluenesulfonyl chloride 
• 189996-60-9 2,3-O-isopropylidene-D-erythrose 

Downstream Products

• 127910-61-6 (1R,5S,6S)-tert-butyl 6-formyl-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane-7-carboxylate 
• 127910-62-7 7-tert-butyl 6-hydrogen (1R,5S,6S)-3,3-dimethyl-2,4-dioxa-7-azabicyclo<3.3.0>octane-6,7-dicarboxylate 
• 144541-71-9 (2S,3S,4R)-3,4-dihydroxyproline trifluoroacetic acid salt 

Relevant academic research and scientific papers

Ketene S,S-Acetals as 1,3-Dipolarophiles: Application to the Synthesis of Polyhydroxylated Pyrrolidines

Two approaches to the synthesis of the hydroxylated pyrrolidines 3 and 4, based on exploiting the reactivity of a ketene S,S-acetal as a 1,3-dipolarophile, are described.Both routes utilize a carbohydrate starting material and the strategy based on D-eryt