1279124-33-2Relevant academic research and scientific papers
B(C6F5)3-Catalyzed Reduction of Cyclic N-Sulfonyl Ketimines
Shi, Lei,Bao, Robert Li-Yuan,Zheng, Limin,Zhao, Rong
supporting information, p. 6550 - 6556 (2019/10/22)
A metal-free method for reduction of cyclic N-sulfonyl ketimines catalyzed by B(C6F5)3, using commercially available methylphenylsilane as a reducing reagent under mild conditions has been developed. This reductive protoco
The construction of chiral fused azabicycles using a Pd-catalyzed allylic substitution cascade and asymmetric desymmetrization strategy
An, Qianjin,Liu, Delong,Shen, Jiefeng,Liu, Yangang,Zhang, Wanbin
supporting information, p. 238 - 241 (2017/11/27)
A highly enantioselective Pd-catalyzed asymmetric allylic substitution cascade of cyclic N-sulfonylimines with an accompanying asymmetric desymmetrization has been developed for the construction of fused tetrahydroindole derivatives bearing two chiral centers. Mechanistic studies confirmed that the cascade reaction proceeds by initial allylic alkylation and subsequent allylic amination. The first alkylation is a chirality-control step and represents an asymmetric desymmetrization of ciscyclic allyl diacetates. The reaction has been performed on a gram scale, and the desired products can take part in several transformations.
Formal palladium-catalyzed asymmetric hydrogenolysis of racemic N -sulfonyloxaziridines
Song, Bo,Yu, Chang-Bin,Huang, Wen-Xue,Chen, Mu-Wang,Zhou, Yong-Gui
, p. 190 - 193 (2015/01/30)
Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.
