127934-54-7

Basic information

• Product Name: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, methyl ester
• CAS NO: 127934-54-7
• Molecular Formula: C16H11NO4
• Molecular Weight: 281.268
• Mol File: 127934-54-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, methyl ester(127934-54-7)
• EPA Substance Registry System: Benzoic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, methyl ester(127934-54-7)

Safety Data

• Hazardous Substances Data: 127934-54-7(Hazardous Substances Data)

Upstream product

• 615-42-9 1,2-Diiodobenzene 
• 201230-82-2 carbon monoxide 
• 619-45-4 4-methoxycarbonyl aniline 
• 1074-82-4 potassium phtalimide 
• 54376-74-8 2-(4-iodophenyl)isoindoline-1,3-dione 
• 85-44-9 phthalic anhydride 
• 540-37-4 p-aminoiodobenzene 
• 93-58-3 benzoic acid methyl ester 
• 136918-14-4 phthalimide 
• 3481-09-2 N-chlorophthalimide 

Relevant articles and documents

Imide arylation with aryl(TMP)iodonium tosylates

Herein, we describe the synthesis of N-aryl phthalimides by metal-free coupling of potassium phthalimide with unsymmetrical aryl(TMP)iodonium tosylate salts. The aryl transfer from the iodonium moiety occurs under electronic control with the electron-rich trimethoxyphenyl group acting as a competent dummy ligand. The yields of N-aryl phthalimides are moderate to high and the coupling reaction is compatible with electron-deficient and sterically encumbered aryl groups.

Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.

Nitrogen-centered radical-mediated C-H imidation of arenes and heteroarenes via visible light induced photocatalysis

The C-H imidation of arenes and heteroarenes has been achieved via visible light induced photocatalysis. In the presence of an iridium(iii) photoredox catalyst, the reaction of aromatic substrates with N-chlorophthalimide furnishes the N-aryl products at room temperature through a nitrogen-centered radical mediated aromatic substitution.