127941-51-9Relevant academic research and scientific papers
Synthesis and biological evaluation of 1′-C-cyano-pyrimidine nucleosides
Yoshimura, Yuichi,Kano, Fumitaka,Miyazaki, Shuichi,Ashida, Noriyuki,Sakata, Shinji,Haraguchi, Kazuhiro,Itoh, Yoshiharu,Tanaka, Hiromichi,Miyasaka, Tadashi
, p. 305 - 324 (2007/10/03)
2′-Deoxy-, 2′-bromo-, and arabino-1′-C-cyano-pyrimidine nucleosides were synthesized from O2,2′-cyclouridine. Incorporation of cyano group at the anomeric position was achieved by treatment of 1′,2′-unsaturated uridine with NBS in the presence of pivalic acid followed by TMS-cyanide and stannic chloride. Antineoplastic and antiviral activities of those compounds are also discussed.
