127949-79-5

Basic information

• Product Name: t-butyl (2S)-1-benzyloxycarbonyl-4-(1-hydroxypropyl)pyroglutamate
• Synonyms: t-butyl (2S)-1-benzyloxycarbonyl-4-(1-hydroxypropyl)pyroglutamate
• CAS NO: 127949-79-5
• Molecular Weight: 377.437
• Mol File: 127949-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: t-butyl (2S)-1-benzyloxycarbonyl-4-(1-hydroxypropyl)pyroglutamate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl (2S)-1-benzyloxycarbonyl-4-(1-hydroxypropyl)pyroglutamate(127949-79-5)
• EPA Substance Registry System: t-butyl (2S)-1-benzyloxycarbonyl-4-(1-hydroxypropyl)pyroglutamate(127949-79-5)

Safety Data

• Hazardous Substances Data: 127949-79-5(Hazardous Substances Data)

Upstream product

• 32159-21-0 Cbz-L-pGlu-OH 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 81470-51-1 tert-butyl N-benzyloxycarbonyl-L-pyroglutamate 
• 123-38-6 propionaldehyde 

Relevant articles and documents

Amino Acid Synthesis Using (L)-Pyroglutamic Acid as a Chiral Starting Material

Deprotonation of protected pyroglutamates 1(c), 1(d), and 1(e) with lithium di-isopropylamine (LDA) or lithium hexamethyldisilazide (LiHDMS) in THF, followed by reaction with electrophiles, leads to the formation of 4-substituted pyroglutamates in good yield.This approach has been used for the synthesis of the novel amino acid (4).Key Words: pyroglutamic acid; chiral amino acid synthesis