81470-51-1

Basic information

• Product Name: Z-Pyr-OtBu
• Synonyms: 1-Benzyl 2-(2-methyl-2-propanyl) (2S)-5-oxo-1,2-pyrrolidinedicarboxylate;1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 2-(1,1-dimethylethyl)1-(phenylmethyl) ester, (S)-;Z-Pyr-OtBu
• CAS NO: 81470-51-1
• Molecular Formula: C₁₇H₂₁NO₅
• Molecular Weight: 319.35234
• Mol File: 81470-51-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Z-Pyr-OtBu(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Pyr-OtBu(81470-51-1)
• EPA Substance Registry System: Z-Pyr-OtBu(81470-51-1)

Safety Data

• Hazardous Substances Data: 81470-51-1(Hazardous Substances Data)

Usage

General Description

Z-Pyr-OtBu is a chemical compound that is commonly used as a building block in the synthesis of various pharmaceuticals and organic materials. It features a pyridine ring with an appended tert-butyl ester functional group, which provides stability and protection to reactive intermediates during chemical reactions. Z-Pyr-OtBu is known for its versatility in organic synthesis, particularly in the preparation of complex molecules for drug development and materials science. Due to its unique structure and reactivity, Z-Pyr-OtBu has found broad applications in the laboratory setting and has contributed to advancements in the fields of chemistry and medicine.

Upstream product

• 16881-39-3 (S)-2-tert-butyl-1-benzylpyrrolidine-1,2-dicarboxylate 
• 32159-21-0 Cbz-L-pGlu-OH 
• 540-88-5 acetic acid tert-butyl ester 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 4124-76-9 N-(benzyloxycarbonyl)-L-glutamic acid anhydride 
• 100-59-4 phenylmagnesium chloride 
• 2398-37-0 3-methoxyphenyl bromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 35418-16-7 L-t-butyl pyroglutamate 
• 31139-36-3 dibenzyl dicarbonate 
• 75-65-0 tert-butyl alcohol 
• 115-11-7 isobutene 
• 57732-63-5 1-tert-butyl 5-methyl (2S)-2-{[(benzyloxy)carbonyl]amino}pentanedioate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 95022-60-9 benzyloxycarbonyl-L-glutamic acid α-tert-butyl ester γ-hydrazide 
• 138858-46-5 tert-butyl (2S)-1-(benzyloxycarbonyl)-4α-(phenylmethyl)pyroglutamate 
• 138858-32-9 tert-butyl (2S)-1-(benzyloxycarbonyl)-4α-(hydroxy(p-methoxyphenyl)methyl)pyroglutamate 
• 138858-32-9 tert-butyl (2S)-1-(benzyloxycarbonyl)-4β-(hydroxy(p-methoxyphenyl)methyl)pyroglutamate 
• 127949-79-5 t-butyl (2S)-1-benzyloxycarbonyl-4-(1-hydroxypropyl)pyroglutamate 
• 599191-10-3 tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxohexanoate 
• 642410-59-1 tert-butyl (2S)-2-[(benzyloxycarbonyl)amino]-5-oxopentadecanoate 
• 1033713-89-1 1-benzyl 2-tert-butyl (2S)-5-methoxypyrrolidine-1,2-dicarboxylate 
• 1033709-22-6 (5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-5-ethyl-L-proline 
• 1033714-59-8 (5R)-1-[(benzyloxy)carbonyl]-5-methyl-L-proline 
• 1033713-91-5 (5R)-1-[(benzyloxy)carbonyl]-5-ethyl-L-proline 
• 1033714-79-2 benzyl (2S,5R)-2-{[(3S)-3,4-dimethylpiperazin-1-yl]carbonyl}-5-methylpyrrolidine-1-carboxylate 
• 1033714-69-0 benzyl (2S,5R)-2-{[(3R)-3,4-dimethylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidine-1-carboxylate 
• 1443977-66-9 (5R)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N,5-trimethyl-L-prolinamide 

Relevant articles and documents

The synthesis of γ-Substituted Glutamic Acids via a Glutamic Acid γ-Enolate Synthon.

Treatment of α-t-butyl γ-methyl N-Z-glutamate (4) with lithium hexamethyldisilazide results in the regiospecific formation of the γ-anion, which reacts with electrophiles to give γ-substituted glutamic acid derivatives.

Selective Electrochemical Oxidation of Functionalized Pyrrolidines

A method for the selective electrochemical aminoxyl-mediated Shono-type oxidation of pyrrolidines to pyrrolidinones is described. These transformations show the high selectivity and functional group compatibility. This chemistry also demonstrates the use of an operationally simple ElectraSyn 2.0 and cost-effective stainless-steel electrode for the electrochemical oxidation of functionalized pyrrolidines.

DIAZABICYCLO[4.3.1]DECANE DERIVATIVES FOR TREATMENT OF PSYCHIATRIC DISORDERS

The present invention relates to diazabicyclo[4.3.1]decane derivatives, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said diazabicyclo[4.3.1]decane derivatives can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.