127949-85-3Relevant academic research and scientific papers
Solution synthesis of a dimeric pentapeptide: Diketopiperazine cyclisation of Glu-Asp dipeptide esters and Asp-racemisation during segment condensation
Fischer,Solbakken,Undheim
, p. 2277 - 2288 (1994)
A haemoregulatory peptide analogue derived from the cystine-dimerised pentapeptide Glp-Glu-Asp-Cys-Lys-OH, in which the cystine residue has been replaced by an isosteric L,L-2,7-diaminosuberic acid moiety, was prepared by segment condensation in solution.
NEW ENZYMATIC APPROACH TO THE SYNTHESIS OF CONVENIENT ASPARATIC ACID INTERMEDIATES IN PEPTIDE CHEMISTRY. SYNTHESIS OF N-BENZYLOXYCARBONYL-L-ASPARATIC ACID β-ALLYL ESTER.
Xaus, N.,Clapes, P.,Bardaji, E.,Torres, J. L.,Jorba, X.,et al.
, p. 7421 - 7426 (2007/10/02)
Asparatic acid side chain protection by allyl ester functions has been facilitated by the direct synthesis of Z-Asp(OAll)-OH which can be performed by selective hydrolysis of Z-Asp(OAll)-OAll by means of papain catalysis.Both an optimization study and a batch synthesis are reported.Other synthesis routes are discussed.
